代谢药物,脂类药物和抗精神病药物:系统性审查
Kyle J Burghardt1, Megan Kajy1, Kristen M Ward2
1Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University Detroit, Detroit, MI 48201, USA.
Biomedicines
|December 23, 2023
概括
代谢学研究揭示了代谢物如酸丁胆和碳酸等代谢物的持续变化,并使用抗精神病药物. 需要进一步的受控研究来验证这些生物标志物对个性化精神病治疗的有效性.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 基因组学就是基因组学.
背景情况:
- 抗精神病药物对于精神疾病治疗至关重要,但患者的反应有很大差异.
- 目前的选择依赖于试错,因为对个体疗效和耐受性的理解有限.
- 代谢学为识别抗精神病反应的生物标志物提供了潜力.
研究的目的:
- 系统地审查与人类抗精神病药物使用相关的代谢物和代谢途径.
- 确定潜在的生物标志物来预测药物的有效性和毒性.
主要方法:
- 对42项关于代谢药和抗精神病药物的人类研究进行了系统审查.
- 分析重点是基于血液的生物样本 (血/血清).
- 在各种研究设计中对14种代谢物和12种脂类进行评估.
主要成果:
- 观察到的一致性干扰:酸丁胆的增加,碳素酸的减少和抗精神病药物暴露时的乙卡尼丁的减少.
- 七种代谢物和三种脂质物种在有针对性的研究中显示了复制的发现.
- 酸盐的减少是有针对性的代谢学研究中最一致的发现.
结论:
- 对抗精神病药物的代谢学研究提供了一个基础,但对元分析需要更标准化的报告.
- 经过验证的生物标志物可以在精神病学中实现个性化医疗方法.
- 未来的研究需要有控制的设计,以尽量减少混因素,并最大限度地发挥代谢学潜力.
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