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增强阿皮基因的溶解和有效性使用甘氨酸喷雾干燥固体分散填充在3D打印的平板电脑
Asma B Omer1, Farhat Fatima2, Mohammed Muqtader Ahmed2
1Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Biomedicines
|December 23, 2023
概括
这项研究开发了glycyrrhizin-apigenin固体分散剂和3D打印的片剂,以改善apigenin (APN) 溶解和癌症治疗. APN2配方显示了增强的药物释放,抗氧化剂和抗癌性质,表明了先进药物递送的潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 原蛋白 (APN) 已证明具有治疗潜力,特别是在癌症治疗中,但具有较差的溶解性和生物可用性.
- 开发先进的药物输送系统对于提高阿皮基宁的治疗疗效至关重要.
研究的目的:
- 制备甘瑞-阿比基宁喷雾干燥固体分散剂和3D打印的片 (printlets) 以增强阿比基宁的溶解和治疗效果.
- 评估开发的配方的物理化学性质,体外溶解,生物活性和稳定性.
- 评估这些先进配方在结肠癌治疗中的潜力.
主要方法:
- 使用喷雾干燥技术制备甘油-原蛋白固体分散剂.
- 开发基于PVA光纤的3D打印机,其中包含固体分散.
- 物理化学表征包括FTIR,粉末-XRD,DSC和流量特性分析.
- 在体外溶解研究,抗氧化剂,细胞毒性和抗菌剂测定.
- 根据ICH指南进行稳定性研究.
主要成果:
- 喷雾干燥固体分散剂 (APN1-APN3) 已成功制备,具有高产量和药物含量.
- 证实了apigenin的无形转化,从而改善了APN2配方的流动性.
- APN2显著增强了体外溶解 (94.65%释放),提高了溶解效率和受控释放特性.
- 对于APN2.2,观察到增强的抗氧化剂,对HCT-116结肠癌细胞的优异细胞毒性,以及增加的抗菌活性.
- APN2配方在90天内表现出良好的稳定性,符合ICH要求.
结论:
- 甘油-原蛋白固体分散和3D打印的小打印机是增强原蛋白溶解和生物可用性的有希望的方法.
- APN2配方显示出优越的物理化学,溶解和生物特性,表明其治疗潜力得到了增强.
- 开发的3D打印技术为改善药物输送和有效治疗结肠癌提供了一个新的平台.
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