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和自闭症谱系障碍:通过全面审查和元分析探索联系
Aleksandar Stojsavljević1, Novak Lakićević2, Slađan Pavlović3
1Innovative Centre, Faculty of Chemistry, University of Belgrade, Studentski Trg 12-16, 11000 Belgrade, Serbia.
Biomedicines
|December 23, 2023
概括
患有自闭症谱系障碍 (ASD) 的儿童的血液和红细胞中的 (Hg) 水平较高,这表明解毒功能受损. 头发和尿液的Hg水平在患有自闭症的儿童中没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 儿科 儿科 儿科
背景情况:
- (Hg) 是一种神经毒剂,已知对中枢神经系统有不良影响.
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 了解环境因素,如Hg暴露,对于ASD研究至关重要.
研究的目的:
- 对ASD儿童与神经类型对照进行各种生物矩阵中Hg水平的综合元分析.
- 在五个临床矩阵中调查性别和年龄匹配的ASD病例和对照之间的Hg水平的潜在差异:头发,全血,血,红细胞 (红细胞) 和尿液.
主要方法:
- 一个系统的审查和对60个同行评审的病例控制研究的元分析.
- 纳入标准侧重于比较ASD儿童与神经类型对照儿童之间头发,全血,血,红细胞和尿液中的Hg水平的研究.
- 排除了涉及接受化疗的儿童的研究.
主要成果:
- 在ASD病例和对照之间,在头发和尿液中没有发现Hg水平的统计学上显著差异.
- 与对照人群相比,在患有ASD的儿童的全血,血和红细胞中观察到显著更高的Hg水平.
- 这些发现表明,ASD儿童的Hg排毒和分泌机制可能存在差异.
结论:
- 患有自闭症的儿童可能有减少解毒和分泌Hg的能力,特别是在血液和红细胞中的更高水平表明.
- 这些发现强调了Hg在自闭症发病过程中的潜在有害作用,并强调了在幼儿时期监测Hg水平的重要性.
- 迫切需要全球倡议,以尽量减少Hg暴露,因为它对神经发育健康的影响.
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