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神经生长因子及其受体在人类精子病理学的可能作用

Anna Maria Stabile¹, Alessandra Pistilli¹, Elena Moretti²

¹Department of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, 06132 Perugia, Italy.

|December 23, 2023

概括

神经生长因子 (NGF) 和它的受体在精子健康中起着不同的作用. 精子中的受体分布变化与男性不孕症有关,这表明了新的治疗点.

科学领域:

生殖生物学生殖生物学
分子内分泌学分子内分泌学
安德罗学与人类学

背景情况:

神经生长因子 (NGF) 信号影响精子生成和精子质量.
在男性生殖组织和精子中NGF及其受体 (p75^NTR,TrKA) 的作用和分布需要进一步阐明,特别是在不孕症的情况下.

研究的目的:

为了研究NGF及其受体 (p75^NTR,TrKA) 的分布和功能,在受孕男性和不孕症男性的丸,上皮和精子中 (静脉瘤,泌尿器官感染).

主要方法:

精液分析包括精子参数,细菌学测试和白细胞识别.
精液血NGF,IL-1β和F₂-异质素的量化.
在精子中评估NGF受体基因和蛋白质表达.
免疫光定位NGF受体在精子,丸和上.

主要成果:

与不育男性相比,生育不良的男性表现出优越的精子参数和较低的精子NGF,F₂-IsoPs和IL-1β水平.
在肥沃的精子中,p75^NTR和TrKA被局限于精子尾部和后体外.
不育精子显示了改变的p75^NTR定位,特别是在中间部分和细胞质残留物中.

结论:

NGF信号传递及其受体分布在肥沃男性和不育男性中是不同的.
精子中的异常NGF受体表达与男性不孕症有关.
这些发现表明了针对男性生殖健康中NGF通路的新型治疗策略的潜力.

关键词:

在TrKA和p75NTRTR.人类精子的人类精子这些神经营养素是神经营养素 (neurotrophins).泌尿器官感染泌尿器官感染这种疾病的发病率是Varicocele.

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