在患有系统性红斑狼的患者中,COVID-19疫苗接种相关的延迟不良事件
Mrinalini Dey1, Bohdana Doskaliuk2, Julius Lindblom3
1Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK.
Journal of clinical medicine
|December 23, 2023
概括
与健康对照组相比,系统性红斑狼 (SLE) 患者在COVID-19疫苗接种后更频繁地住院和延迟不良事件 (DAE). 疫苗接种后监测SLE患者对于早期检测和支持至关重要,特别是对于那些患有自身免疫多病症的人来说.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗的安全性已经确立,但由于长期安全性数据有限,免疫受损的个体患有免疫媒介炎症疾病仍然犹不决.
- 与其他自身免疫性疾病和健康对照相比,在系统性红斑狼 (SLE) 中对COVID-19疫苗接种后的延迟不良事件 (DAE) 的评估至关重要.
研究的目的:
- 评估SLE.患者接种COVID-19疫苗后延迟不良事件 (DAE) 的发生率和类型.
- 将SLE患者的DAE与其他类风湿性自身免疫疾病 (rAIDs),非类风湿性自身免疫疾病 (nrAIDs) 和健康对照 (HCs) 的DAE进行比较.
主要方法:
- 利用来自全球150个中心的COVID-19疫苗接种对自身免疫性疾病 (COVAD) -2在线调查 (2022年2月至6月) 的数据.
- 使用后勤回归分析,根据年龄,性别和种族进行调整,以在不同患者组和对照组中比较DAE.
主要成果:
- 与HC患者相比,SLE患者报告的重大DAE和住院病例显著增加.
- SLE患者比rAID患者更频繁地出现严重皮疹,住院和轻微的DAE比rAID患者的比例更高.
- Moderna 疫苗与更频繁的住院病例有关; SLE 患者与并发性 nrAIDs 报告的小 DAE 比没有.
结论:
- 在COVID-19疫苗接种后住院的情况在SLE患者中比HC患者更为常见.
- 疫苗接种后对SLE患者的密切监测有助于早期DAE识别和患者支持.
- 告知患者关于潜在的DAE是必不可少的,特别是对于那些自身免疫多病症患者来说.
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