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Updated: Jul 7, 2025

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Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
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生活在口服抗凝剂:杜克抗凝满意度度表结果
Antonella Mameli1, Alessandro Sestu1, Francesco Marongiu2
1Department of Internal Medicine, Azienda Ospedaliero-Universitaria di Cagliari, 09123 Cagliari, Italy.
Journal of clinical medicine
|December 23, 2023
概括
与维生素K抗剂 (VKA) 相比,直接口服抗凝剂 (DOAC) 显著改善患者的生活质量. 这项现实研究发现,DOACs导致长期抗凝剂治疗患者的日常限制和负担减少.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 心血管医学 心血管医学
- 患者报告的结果
背景情况:
- 直接口服抗凝剂 (DOAC) 越来越多地用于心房动和静脉血栓塞栓症,比维生素K对抗剂 (VKA) 有优势.
- 在现实环境中,DOAC与VKA对患者生活质量 (QoL) 的影响需要全面评估.
- 诸如年龄,性别,教育,药物治疗方案和并发症等因素可能会影响抗凝药患者的QoL.
研究的目的:
- 为了前性地评估和比较患者的长期生活质量治疗DOACs与VKAs.
- 为了确定与DOAC和VKA治疗之间的QoL差异相关的患者相关变量.
主要方法:
- 在2021年1月至12月期间进行的一项前性观察队列研究.
- 杜克抗凝血满意度尺度 (DASS) 通过面试进行,以评估VKA或DOAC患者的QoL.
- 在整个随访期间,患者被密切监测出血和血栓事件.
主要成果:
- 该研究包括300名接受VKA治疗的患者和254名接受DOAC治疗的患者.
- 接受DOAC治疗的患者报告生活质量明显改善 (平均DASS得分:44.7),与接受VKA治疗的患者相比 (平均DASS得分:51.0;p < 0.0001).
- 与VKA治疗相比,DOAC治疗与较少的日常生活限制,麻烦,负担以及减少的心理影响有关.
结论:
- 维生素K抗体 (VKA) 对患者的日常生活产生负面影响,导致满意度降低,任务耗时增加.
- 直接口服抗凝剂 (DOAC) 为需要长期抗凝剂治疗的患者提供了更好的生活质量.
- 患者对DOAC治疗缺乏直接监测的担忧需要进一步调查,以优化患者体验.
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