卡尔蛋白蛋白与炎症性肠病中的HETE和HODE酸有关
Małgorzata Szczuko1, Paulina Komisarska1, Justyna Kikut1
1Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 72-009 Police, Poland.
Journal of clinical medicine
|December 23, 2023
概括
炎症性肠病患者表现出不同水平的脂肪酸代谢产物. 在性结肠炎中,特定的氧易可沙特酸 (HETE) 与calprotectin水平相关,为疾病活动提供了洞察力.
科学领域:
- 胃肠道学和免疫学
- 生物化学和分子生物学
- 自身免疫性疾病研究研究
背景情况:
- 肠道疾病与潜在由病毒感染引发的自身免疫反应有关.
- 炎症性肠道疾病 (IBD) 的复杂病因因素对有效治疗构成了挑战.
- 之前的研究表明,炎症标记物calprotectin与氧酸酸 (HETE) 和氧十甲酸 (HODE) 化合物之间存在联系.
研究的目的:
- 在IBD患者中调查calprotectin度和特定的酸衍生物之间的关系.
- 探索这些代谢物与克罗恩病 (CD) 和性结肠炎 (UC) 疾病特征之间的潜在相关性.
主要方法:
- 分析了62名儿科IBD患者.
- 使用酶相关免疫吸收试验 (ELISA) 测量了calprotectin水平.
- 使用液态染色学量化HETE和HODE度.
主要成果:
- 克罗恩病患者的脂肪酸代谢物水平较高,但没有发现calprotectin相关性.
- 年龄与CD中的12S HETE,UC中的15 HETE和5 oxoETE相关.
- 在UC中,5-HETE和12-HETE与calprotectin水平呈正相关性.
结论:
- 特定的HETE代谢物与UC活性和持续时间有关.
- HETE酸似乎在UC进展中发挥着重要作用.
- 这些发现可能有助于监测炎症状态并指导IBD的治疗干预.
相关概念视频
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
188
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
188
01:30Inflammatory Bowel Disease II: Crohn's Disease
251
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
251
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
01:17Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
01:29Drugs for Treatment of Ulcerative Colitis in IBD
145
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
145
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
141
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
141