住院COVID-19阳性患者中的死亡和静脉血栓栓塞分析:一个多中心研究
Asma Alshahrani1, Abdullah Almoahzieie2,3, Hanan Alshareef4
1Department of Clinical Pharmacy, Faculty of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
Journal of clinical medicine
|December 23, 2023
概括
住院的COVID-19患者面临着显著的死亡风险和高发生率的静脉血栓栓塞 (VTE),特别是那些患有癌症. 在高风险人群中,对VTE的密切监测至关重要.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 凝血障碍在2019年冠状病毒病 (COVID-19) 患者中很常见,特别是那些症状严重的人.
- 住院COVID-19患者表现出血栓事件的风险增加.
- 了解COVID-19中的死亡率和静脉血栓栓塞 (VTE) 非常重要.
研究的目的:
- 为了确定住院COVID-19患者的死亡率.
- 为了确定该人群中VTE的发病率.
- 为了确定与COVID-19中VTE相关的风险因素.
主要方法:
- 追溯观察队列研究.
- 包括实验室证实COVID-19的成年患者.
- 多变量逻辑回归分析以确定VTE预测因子.
主要成果:
- 在1024名COVID-19患者中,有10.7%死亡;5.7%患有VTE.
- 死亡率在50岁以上的患者中,在ICU和机械通风中更高.
- 癌症患者的VTE风险显著增加 (aOR=2.614,p=0.039).
结论:
- 住院COVID-19患者的死亡率和VTE患病率很高,尤其是那些患有癌症的人.
- 在所有COVID-19患者中,抗凝固疗法可能无法完全减轻VTE风险.
- 对于高风险的COVID-19患者,建议对VTE进行警监测.
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