相关实验视频

Updated: Jul 7, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

在神经内分泌新生体转移到肝脏和骨的肝脏导向治疗

Kristen E Limbach¹, Kelly M Mahuron¹, Aaron T Scott¹

¹Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.

Journal of clinical medicine

|December 23, 2023

概括

以肝脏为导向的治疗 (LDT) 可能会改善胃肠瘤神经内分泌瘤 (GEPNEN) 和骨转移的患者的存活率. 在骨转移诊断后接受LDT显示,与没有LDT相比,存活率有好处.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
医疗数据分析医学数据分析

背景情况:

胃肠道胰腺神经内分泌瘤 (GEPNENs) 的骨转移与预后不佳有关.
肝导向治疗 (LDT) 对GEPNENs患者与同时发生骨转移的生存影响尚不清楚.

研究的目的:

调查LDT对被诊断为GEPNEN转移到肝脏和骨的患者的生存益处.
根据LDT相对于骨转移诊断的时间来比较生存结果.

主要方法:

加利福尼亚癌症登记处和全州医院数据 (2000-2012年) 的回顾性分析.
包括203名GEPNEN转移到肝脏和骨的患者.
将患者分为几组:骨转移后的LDT,骨转移前的LDT和没有LDT.

主要成果:

与从未接受LDT的患者相比,在骨转移诊断后接受LDT的患者的平均整体存活时间明显长 (p = 0.005).
在骨转移诊断后接受LDT的患者的生存结果与诊断前接受LDT的患者没有显著差异 (p = 0.256).
很大一部分患者 (63.1%) 没有接受任何LDT.

结论:

以肝脏为导向的治疗可能会提供生存优势,即使在GEPNENs的骨转移诊断后给予治疗.
晚期治疗的时间 (骨转移诊断之前或之后) 可能不会显著改变生存益处,这表明它在晚期疾病阶段的有用性.

关键词:

骨转移的发生.以肝脏为导向的治疗方法.神经内分泌瘤的神经内分泌瘤

更多相关视频

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...