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红细胞输血中的性别差异和心脏外科手术中的30天死亡率:单中心观察性研究
Jenni Räsänen1,2, Sten Ellam3, Juha Hartikainen1,2
1Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
Journal of clinical medicine
|December 23, 2023
概括
接受心脏手术的女性接受红细胞 (RBC) 输血的可能性显著增加,独立于其他因素. 红细胞输血与男女30天死亡率的增加有关.
科学领域:
- 心血管外科心血管外科
- 输血医学 输血医学
- 临床结果研究研究
背景情况:
- 与男性相比,接受心脏手术的女性的短期死亡率更高,红细胞输血率增加.
- 现有的研究表明,术后护理和心脏手术中的结果可能存在基于性别的差异.
研究的目的:
- 为了研究心脏手术后红细胞输血率的性别差异.
- 检查红细胞输血,手术前血红蛋白,体重指数 (BMI) 和接受心脏手术的男性和女性30天死亡率之间的关联.
主要方法:
- 单中心回顾性研究包括1583名接受心脏手术的患者 (1181名男性,402名女性).
- 采用多变量分析来确定红细胞输血的独立预测因子.
- 分析的结果包括红细胞输血率,手术前因素 (血红蛋白,BMI) 和30天死亡率.
主要成果:
- 与男性 (33.0%) 相比,女性的红细胞输血率 (64.4%) 显著更高.
- 女性性别是输血红细胞的独立预测因素 (OR 3.88,95% CI 2.95-5.11,p < 0.001),以及年龄,手术前血红蛋白和BMI.
- 红细胞输血与两性30天死亡率的增加有关.
结论:
- 接受心脏手术的女性比男性更有可能接受红细胞输血,无论手术类型如何.
- 手术前的血红蛋白水平同样预测了两种性别的输血风险,而BMI的影响因性别而异.
- 红细胞输血独立地与男性和女性心脏手术患者的30天死亡率较高有关,这突显了输血优化需求.
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