手术切除心脏血管肉瘤:国家癌症数据库的生存分析
Mohamed Rahouma1,2, Massimo Baudo1,3, Sherif Khairallah1,2
1Cardiothoracic Surgery Departments, Weill Cornell Medicine, New York, NY 10065, USA.
Journal of clinical medicine
|December 23, 2023
概括
手术与其他治疗相结合,可以改善心脏血管肉瘤的存活率,这是一种罕见且具有攻击性的癌症. 年龄较大和非白人/黑人种族预测这些患者的结果更差.
科学领域:
- 在瘤学瘤学.
- 心血管外科心血管外科
- 医学统计 医学统计
背景情况:
- 心脏血管肉瘤是一种罕见的,高等级的软组织肉瘤,起源于内皮细胞.
- 它的特点是侵略性行为和整体生存率差.
研究的目的:
- 为了研究手术在初级心脏血管瘤中的作用.
- 为了确定晚期死亡率的预测因素.
- 探索手术和其他治疗方式之间的相互作用.
主要方法:
- 对2004-2017年国家癌症数据库对初级心脏血管肉瘤患者的分析.
- 卡普兰-梅尔曲线和考克斯回归分析用于晚期死亡预测因素.
- 基于治疗策略的生存结果的评估.
主要成果:
- 在130名患者中进行了手术;中位数的整体存活 (OS) 为14.32个月.
- 综合模式治疗 (手术+其他) 的中位数寿命为17.28个月,仅手术为2.88个月 (p=0.018).
- 年龄较大 (>57岁) 与较低的生存率和不那么积极的治疗有关,年龄和种族 (除白人/黑人以外) 作为独立的死亡率预测因素.
结论:
- 心脏血管肉瘤的预后不好.
- 包括手术在内的多模式治疗对于改善生存率至关重要.
- 年龄和种族是影响心脏血管肉瘤患者死亡率的重要因素.
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