对口腔真菌抽样和患者血液检测数据之间的关系的探索性研究
Tatsuki Itagaki1,2, Ken-Ichiro Sakata1, Akira Hasebe2
1Oral Diagnosis and Medicine, Faculty of Dental Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7, Kita-ku, Sapporo 060-8586, Japan.
Microorganisms
|December 23, 2023
概括
衰老和低血清白蛋白水平增加了口腔候群病的风险. 这项研究研究了口腔酵母感染,为预防和治疗策略提供了见解.
科学领域:
- 口腔医学是指口腔医学.
- 菌类学 菌类学是指菌类学.
- 公共卫生 公共卫生
背景情况:
- 口腔角膜炎是一种由Candida物种引起的感染,与各种系统性疾病有关.
- 最近的进展改善了对口腔微生物组及其系统影响的理解.
- 进一步调查口腔角膜炎的风险因素对于有效管理至关重要.
研究的目的:
- 调查与口腔候群病相关的危险因素.
- 为了确定口服Candida物种流行率和患者人口统计学/生化标志物之间的相关性.
- 为预防和治疗口腔角膜炎提供见解.
主要方法:
- 314名患者的队列接受了使用MALDI生物型号进行Candida物种识别的口服抽样测试.
- 收集的数据包括年龄,性别,血细胞计数,血红蛋白,总蛋白质,维生素B12,血清白蛋白,铁,铜和水平.
- 统计分析包括对共变量和多变量逻辑回归的分析.
主要成果:
- 口腔角膜炎的患病率与性别没有显著关联 (p = 0.946).
- 在口腔角膜炎和衰老之间发现了显著的关联 (几率比:1.03).
- 较低的血清白蛋白水平与增加口腔候群病风险显著相关 (几率比:0.32).
结论:
- 老龄化是患口腔候群病的重要危险因素.
- 血清白蛋白水平与口腔候群病的风险相反相关.
- 调查结果为口腔角膜炎的有针对性的预防和治疗策略提供了宝贵的见解.
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