在腹腔疾病中HLA-DQ2/8和COVID-19:好处或坏处
Aaron Lerner1,2, Carina Benzvi1, Aristo Vojdani3
1The Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Ramat Gan 5262160, Israel.
Microorganisms
|December 23, 2023
概括
由于特定的HLA-DQ2/8等位基因,某些患有乳病 (CD) 的个人可能受到严重COVID-19的保护. 这些等位基因可能通过与普通感冒冠状病毒的交叉反应来提供保护.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 传染病流行病学 传染病流行病学
背景情况:
- 由于病毒突变,SARS-CoV-2流行病持续存在,对对严重COVID-19的保护因素的理解有限.
- 流行病学数据表明,病患者的COVID-19发病率较低,暗示了潜在的保护机制.
- 遗传因素,特别是人类白细胞抗原 (HLA) 基因在COVID-19结果中的作用需要进一步调查.
研究的目的:
- 为了调查CD患者中常见的HLA-DQ2/8等位基因是否能对严重的COVID-19结果提供保护.
- 探讨HLA-DQ2/8等位基因可能通过与普通感冒冠状病毒 (CCC) 的交叉反应来保护CD患者的假设.
- 评估SARS-CoV-2表位体与HLA-DQ2/8等位体的结合亲和力 (BA).
主要方法:
- 对SARS-CoV-2和四种与人类相关的CCC之间的序列相似性的计算分析.
- 来自SARS-CoV-2的免疫主导15-mer表位的识别,具有CCC的高序列相同性.
- 鉴定出来的表位体对HLA-DQ2/8等位体的结合亲缘关系 (BA) 的评估.
主要成果:
- 分析显示了924个独特的15-mer表位,其中至少67%的SARS-CoV-2和CCC之间的序列相同.
- 其中,37个表位体表现出对HLA-DQ2/8等位体具有显著的结合亲和力 (BA).
- 这些发现表明HLA-DQ2/8在CD患者中对SARS-CoV-2具有潜在的保护作用.
结论:
- 在CD患者中,HLA-DQ2/8等位基因可能会在一定程度上保护他们免受严重的COVID-19.
- 潜在的机制包括T细胞交叉反应,由先前暴露于CCC引起的.
- 需要进一步的研究来验证这些发现,并探索COVID-19的治疗应用.
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