低尿液自由皮质醇作为患有水出血的患者的危险因素
Ioanna Aggeletopoulou1, Efthymios P Tsounis1, Maria Kalafateli1
1Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.
Medicina (Kaunas, Lithuania)
|December 23, 2023
概括
低24小时尿液自由皮质醇 (UFC) 可能表明肝硬化和水出血患者的风险较高. 需要进一步的研究来确认UFC是这种患者群体上上腺皮质醇产生的可靠指标.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 临床化学 临床化学
背景情况:
- 目前的皮质醇评估方法在准确诊断相对上腺功能不足方面存在局限性.
- 自由皮质醇测试更准确,但由于成本和时间,对于常规临床使用是不切实际的.
- 正在探索其他方法,如唾液皮质醇和间接测量.
研究的目的:
- 为了研究24小时尿液自由皮质醇 (UFC),自由血皮质醇,血清总皮质醇和唾液皮质醇在水出血中的相关性.
- 为了评估UFC对肝硬化患者的死亡率和治疗失败的预测价值.
主要方法:
- 研究了40名肝硬化和水出血的门诊患者.
- 在血清,唾液和尿液中测量了自由皮质醇,使用电化学发光免疫测试.
- 使用单个四极质谱仪量化了无血皮质醇.
主要成果:
- UFC显示与自由血皮质醇有显著的相关性.
- UFC与查尔德-普格 (CP) 评分和C反应蛋白 (CRP) 水平负相关.
- 低UFC水平与CPC阶段C患者的再出血,感染,死亡和更高的死亡风险有关.
结论:
- 低UFC水平可能是肝硬化和水出血患者的危险因素.
- 需要进一步调查UFC作为上腺皮质醇生产指标的潜力.
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