肠道微生物群的氧沙酸降解活性及其对患有功能衰竭的患者心血管健康的影响:试点前性研究
Natalia Stepanova1,2, Ganna Tolstanova2, Iryna Aleksandrova3
1State Institution "Institute of Nephrology of the National Academy of Medical Sciences of Ukraine", 04050 Kyiv, Ukraine.
Medicina (Kaunas, Lithuania)
|December 23, 2023
概括
肠道微生物群氧沙酸降解活性 (ODA) 的降低与替代疗法 (KRT) 患者心血管疾病 (CVD) 风险的增加有关. 这表明,ODA可能是预防心血管疾病的新疗法目标.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 心血管疾病 (CVD) 是接受置换疗法 (KRT) 的患者的一个主要问题.
- 人们越来越认识到肠道微生物群在代谢健康和疾病中的作用.
- 肠道微生物的氧酸盐降解活性 (ODA) 可能会影响宿主健康,但其与KRT患者心血管疾病的联系尚未探索.
研究的目的:
- 调查肠道微生物群的氧酸盐降解活性 (ODA) 与发生心血管疾病 (CVD) 风险之间的关联.
- 探索在接受置换疗法 (KRT) 的患者中将ODA和CVD联系在一起的潜在机制.
- 评估ODA与其他心血管疾病风险因素 (如血氧酸和炎症) 之间的关系.
主要方法:
- 未来观察试点研究涉及32名KRT患者和18名健康对照.
- 测量全便ODA,血氧酸,硫酸,脂质样本,氧化应激和炎症标志物.
- 对心血管疾病事件的三年随访.
主要成果:
- 与健康对照组相比,KRT患者的便ODA显著降低 (p=0.017).
- 负的ODA状态与三年内心血管疾病事件的4.1倍更高的风险相关 (p=0.003).
- 负的ODA状态与血氧酸,硫酸,脂质不良,氧化应激和炎症的升高相关.
结论:
- 减少肠道微生物群的ODA是KRT患者心血管疾病的重要危险因素.
- 这些发现表明,ODA通过涉及氧酸盐代谢,炎症和氧化应激的机制影响心血管疾病风险.
- 向肠道微生物群的ODA可能为KRT患者的心血管疾病预防提供了一个新的治疗策略.
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