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Updated: Jul 7, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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揭示极其有害的IRAK4变体及其对IRAK4抑制剂有效性的潜在影响

Mohammed Y Behairy1, Refaat A Eid2, Hassan M Otifi2

  • 1Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt.

Journal of personalized medicine
|December 23, 2023
PubMed
概括

这项研究确定了IRAK4基因中的十种有害的误解变异,影响蛋白质功能和稳定性. 这些IRAK4基因变异影响抑制剂的有效性,有助于疾病预测.

关键词:
国家统一计划 (SNP) 是一个国家统一计划.TLR信号传输系统的信号.生物信息学是一种生物信息学.这是先天免疫力.分子动力学分子动力学

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