解决的蛋白尿可能会减轻心力衰竭的风险:全国性基于人口的队列研究
Yoonkyung Chang1, Min Kyoung Kang2, Moo-Seok Park2
1Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 08209, Republic of Korea.
Journal of personalized medicine
|December 23, 2023
概括
持续的蛋白尿明显增加了心力衰竭 (HF) 的风险. 然而,解决蛋白尿症可以降低这种风险,突出显示脏健康和心血管结果之间的动态关系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 蛋白尿是心力衰竭 (HF) 的已知危险因素.
- 蛋白尿的可逆性和持续性可以影响其对HF发展的影响.
- 了解蛋白尿状态的变化对于预测心血管风险至关重要.
研究的目的:
- 调查蛋白尿状态的变化与随后患心力衰竭的风险之间的关联.
- 为了在不同蛋白尿路径中比较心力衰竭风险:无蛋白尿,解决,发达和持久.
主要方法:
- 利用韩国国家健康查队列,在2003-2004年和2005-2006年期间检查了1,703,651名参与者.
- 在两个检查期内根据蛋白尿状态将参与者分为四组.
- 用多变量Cox比例危险回归分析进行风险评估,平均随访时间为14.04年.
主要成果:
- 与没有蛋白尿症的参与者相比,持久性蛋白尿症的参与者表现出明显更高的HF风险 (HR: 2.19,95% CI: 2.03-2.36,p < 0.001).
- 蛋白尿症消失的个体与持续蛋白尿症的人相比,HF的风险相对较低 (HR:0.64,95%CI:0.58-0.70,p <0.001).
- 在随访期间,心力衰竭发生在总队列的4.41%中.
结论:
- 蛋白尿状态的变化与心力衰竭的风险显著相关.
- 持续的蛋白尿与高血压风险增加有关,而缓解可能会减轻这种风险.
- 监测和管理蛋白尿状态对于心血管风险分层和预防很重要.
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