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SIGLEC-5/14 抑制CD11b/CD18整合素激活和中性粒细胞介导的瘤细胞细胞毒性

Panagiota Bouti1, Colin Blans1, Bart J A M Klein1

  • 1Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.

International journal of molecular sciences
|December 23, 2023
PubMed
概括

瘤细胞可以通过与中性粒细胞受体SIGLEC-5/14接触酸,抑制抗瘤活性来逃避免疫攻击. 阻止这种相互作用增强了中性粒细胞介导的瘤细胞杀伤,提供了一个新的先天免疫检查点目标.

关键词:
西格莱克 (SIGLEC) 是一个小鸟.抗体疗法是一种抗体疗法.检查站封锁检查站封锁中性粒细胞ADCC的发生.酸是酸的一种.

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