爱斯坦-巴尔病毒和人类内源性逆转录病毒在日本患有自身免疫性脱线性疾病的患者中
Davide Cossu1,2,3, Yuji Tomizawa1, Leonardo Antonio Sechi3,4
1Department of Neurology, Juntendo University, Tokyo 1138431, Japan.
International journal of molecular sciences
|December 23, 2023
概括
埃普斯坦-巴尔病毒 (EBV) 抗体在多发性硬化症 (MS) 和MOGAD患者中升高,表明EBV.
科学领域:
- 神经免疫学 神经免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 多发性硬化症 (MS),神经髓炎光学谱系障碍 (NMOSD) 和MOGAD是不同的自身免疫性脱髓化疾病.
- 这些疾病的确切原因尚不清楚,但怀疑是遗传和环境因素,包括病毒.
- 爱斯坦-巴尔病毒 (EBV) 和人类内源性逆转录病毒-W (HERV-W) 都与自身免疫性疾病有关.
研究的目的:
- 调查日本MS,NMOSD和MOGAD患者对EBV和HERV-W的抗体的存在.
- 将患者的抗体水平与健康对照组 (HCs) 的抗体水平进行比较.
主要方法:
- 从114名日本参与者 (34名MS,20名NMOSD,20名MOGAD,40名HC) 的血清样本进行了回顾性分析.
- 酶相关免疫吸收试验 (ELISA) 用于检测针对特定EBV和HERV-W的抗体.
主要成果:
- 在MS和MOGAD患者中,与HC患者相比,发现针对EBV核抗原1 (EBNA1) 的抗体反应显著更高386-405.
- 在一些MS患者中观察到EBNA1386-405和HERV-W486-504的抗体之间的相关性.
结论:
- 这些发现表明,爱斯坦-巴尔病毒 (EBV) 在MS和潜在的MOGAD的发展中起着作用.
- 在这些神经疾病中,EBV可能会导致HERV-W的重新激活.
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