低臭氧度治疗后血液分子成分的修改
Chiara Rita Inguscio1, Barbara Cisterna1, Flavia Carton1
1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.
International journal of molecular sciences
|December 23, 2023
概括
在绵羊血液中低剂量氧-臭氧 (O2-O3) 治疗可以提高抗氧化能力和氧化. 这项研究揭示了新的代谢途径影响,特别是氨基酸,碳水化合物,脂质和核酸,对于维持氧化剂-抗氧化剂平衡和能源生产至关重要.
科学领域:
- 生物化学 生物化学
- 医学生理学 医学生理学
- 臭氧治疗研究研究臭氧治疗研究
背景情况:
- 活体氧-臭氧 (O2-O3) 血液治疗是一种常见的医疗程序.
- 臭氧 (O3) 作为一种信使,诱导抗氧化和抗炎反应.
- 低剂量O3的使用越来越多,但其分子效应需要进一步研究.
研究的目的:
- 为了研究羊血中的分子修饰,羊血被用低度的O3.
- 阐明5和10μg O3/mL O2对血液新陈代谢的影响.
- 了解这些修改在氧化剂-抗氧化剂平衡和能源生产中的作用.
主要方法:
- 用气态氧-臭氧 (O2-O3) 混合物对绵羊血液进行5和10μg/mL的ex vivo处理.
- 综合的代谢学分析.
- 血液气体分析,光显微镜和生物分析分析.
主要成果:
- 氧3治疗增加了血液的氧化和抗氧化能力.
- 确定了氨基酸,碳水化合物,脂质和核酸代谢的显著变化.
- 改性代谢物主要与氧化剂-抗氧化剂平衡和能量生产有关.
结论:
- 低剂量O3在体外显著影响血液代谢.
- 这些代谢变化有助于保持氧化剂-抗氧化剂平衡和能量平衡.
- 这些发现为低剂量O3治疗的分子机制提供了新的见解.
相关概念视频
Oxygen Transport in the Blood
2.7K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.7K
Oxidation of Phenols to Quinones
3.1K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.1K
Radical Autoxidation
2.1K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.1K
Respiration and Gaseous Exchange
1.5K
The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves...
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves...
1.5K
Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
221
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
221


