细菌病毒强迫细菌O-抗原盾牌:从菌体中吸取教训
1Winogradsky Institute of Micrbiology, Research Center Fundamentals of Biotechnology RAS, pr. 60-letiya Oktyabrya 7 bld. 2, Moscow 117312, Russia.
International journal of molecular sciences
|December 23, 2023
概括
外膜 大肠杆菌中的O-抗原多糖体 (OPS) 起到强大的屏蔽作用,阻断菌体 (菌体) 进入. 菌体已经进化了克服这一重大障碍的机制,影响了细菌生态和菌体-宿主进化.
科学领域:
- 微生物学 微生物学
- 细菌学 细菌学是一门学科.
- 病毒学 病毒学
背景情况:
- 格兰阴性细菌具有带有脂聚糖 (LPS) 的外膜 (OM).
- LPS包括O抗原多糖体 (OPS),它们表现出高度的菌株特异性变异,在大肠杆菌中有超过188种血清型.
- OPS可以作为菌体受体,但也可以屏蔽OM蛋白和其他受体.
研究的目的:
- 审查有关大肠杆菌O抗原多糖 (OPS) 在保护细菌细胞免受菌体 (菌体) 的作用的证据.
- 分析OPS如何影响菌体与宿主相互作用,细菌生态和共同进化.
- 探索菌体机制来克服OPS介导的耐药性.
主要方法:
- 对大肠杆菌O抗原多糖体 (OPS) 和细菌 () 相互作用的现有数据的文献综述和分析.
- 检查OPS作为对菌体感染的主要盾牌的证据.
- 研究菌体策略以透或绕过OPS层.
主要成果:
- 大多数大肠杆菌OPS类型有效地屏蔽细胞,防止菌体进入OM表面.
- 这种屏蔽不仅会影响毒性菌体,还会影响菌体的获取.
- 由OPS介导的屏蔽是大肠杆菌生态和菌体与宿主共同进化的重要因素.
结论:
- 通过OPS介导的OM屏蔽是对大肠杆菌 (E. coli) 和可能是其他阴性细菌中的菌体的细菌耐药性的关键和广泛的机制.
- 菌体已经发展出各种机制来克服OPS障碍,包括RBP对OPS或替代受体的识别.
- 菌体感染涉及通过发动机或结构变化产生机械力以穿透OPS层.
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