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雅卡林-库尔库明复合物使乳腺癌细胞系MDA-MB-231变得敏感

Lidiya Petrova1, Nikolay Gergov2, Marie Stoup3

  • 1Department of Biology, Medical University-Pleven, "St. Kliment Ohridski" Str. 1, 5800 Pleven, Bulgaria.

International journal of molecular sciences
|December 23, 2023
PubMed
概括

这项研究探讨了雅卡林和黄素之间的相互作用,这是一个潜在的癌症药物输送系统. 雅卡林-库尔库明复合物有效地抑制了三阴性乳腺癌细胞的生长.

关键词:
在MDA-MB-231中使用.乳腺癌细胞 乳腺癌细胞库尔库明是一种黄素.细胞毒性 细胞毒性光是一种光.雅卡林 (jacalin) 是一种.蛋白联体相互作用

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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...