Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

498
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
498

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Macrophage-fibroblast signaling networks identified by single-cell RNA sequencing in juvenile systemic sclerosis.

JCI insight·2026
Same author

Autologous stem cell transplantation (ASCT) for Refractory juvenile-onset systemic sclerosis (JSSc).

Annals of the rheumatic diseases·2026
Same author

Are we ready to predict progressive disease in juvenile systemic sclerosis?

Journal of scleroderma and related disorders·2026
Same author

Measuring disease activity in juvenile systemic sclerosis: a multidisciplinary consensus from the Hamburg 2024 symposium.

Expert review of clinical immunology·2026
Same author

Case Report: Sustained immune and pulmonary recovery three years after hematopoietic stem cell transplantation for ITCH E3 ubiquitin ligase deficiency.

Frontiers in immunology·2026
Same author

Decoding spatial transcriptomics across multicellular and subcellular resolutions.

Nature communications·2026

相关实验视频

Updated: Jul 7, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

134.8K

在局部性硬皮病中合成核酸抗原.

Sangita Khatri1, Adrian H Bustos1, Christian Damsgaard Jørgensen2,3

  • 1Department of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

International journal of molecular sciences
|December 23, 2023
PubMed
概括
此摘要是机器生成的。

合成核酸抗原序列会影响局部性硬皮病的自身免疫反应. 一种特定的DNA抗原dsD4,与疾病活动密切相关,在这种自身免疫性皮肤疾病中显示出早期诊断工具的潜力.

关键词:
这是自身免疫力.dsD4D4 在线阅读局部性硬化皮肤病局部性硬化皮肤病合成核酸抗原是一种抗原.

更多相关视频

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

14.1K
Synthetic Antigen Controls for Immunohistochemistry
09:30

Synthetic Antigen Controls for Immunohistochemistry

Published on: August 23, 2021

2.6K

相关实验视频

Last Updated: Jul 7, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

134.8K
Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

14.1K
Synthetic Antigen Controls for Immunohistochemistry
09:30

Synthetic Antigen Controls for Immunohistochemistry

Published on: August 23, 2021

2.6K

科学领域:

  • 免疫学 免疫学 免疫学
  • 皮肤病学 皮肤病学
  • 分子生物学分子生物学

背景情况:

  • 局部性硬是一种自身免疫性皮肤疾病.
  • 反-DNA抗体在自身免疫性疾病中很常见,如狼和局部性硬皮病.
  • 核酸抗原的特定序列可能会影响自身免疫反应.

研究的目的:

  • 为了研究合成核酸抗原序列对局部性硬性皮肤的自身抗体配置的影响.
  • 为了确定特定的核酸序列是否与疾病活性相关.
  • 为了探索局部性硬化症的潜在诊断标志物.

主要方法:

  • 合成了一组DNA和RNA抗原.
  • 在70名患有局部性硬皮病的儿童,健康对照组和儿科狼患者中进行了自身抗体分析.
  • 利用白胺诱导的小鼠模型来确认体内发现.

主要成果:

  • 一种合成的DNA抗原dsD4 (含有BRAF瘤基因序列) 在局部性硬皮病患者中表现出强烈的存在,与系统性红斑狼不同.
  • dsD4自身抗体水平与局部性硬性皮肤病患者的疾病活性有显著相关性.
  • 在体内给予dsd4时,在小鼠模型中诱导了多克隆反应.

结论:

  • 核酸抗原序列的特异性在局部性硬化皮肤病自身免疫性中起作用.
  • dsD4自身抗体代表了局部性硬皮瘤的潜在生物标志物.
  • 这些研究结果表明,对于局部性硬化皮质的新型早期诊断工具的可能性很大.