糖尿病血管和神经病症并发症的细胞疗法:我们可以避免截肢吗?

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Bernat Soria^1,2,3, Natalia Escacena⁴, Aitor Gonzaga^1,2

¹Institute of Biomedical Research ISABIAL of the University Miguel Hernández, Dr. Balmis General and University Hospital, 03010 Alicante, Spain.

International journal of molecular sciences

|December 23, 2023

概括

细胞疗法为糖尿病足 (DFU) 和关键四肢缺血症 (CTLI) 的截肢提供了一个有希望的替代方案. 使用单核细胞 (MNCs) 和介酶体 stromal 细胞 (MSCs) 的治疗促进愈合并防止肢体损失.

科学领域:

再生医学是一种再生医学.
血管生物学血管生物学
糖尿病学糖尿病学

背景情况:

糖尿病足 (DFU) 导致85%的腿部截肢,通常是由于外周动脉疾病 (PAD).
没有选择的关键四肢缺血症 (CTLI) 通常需要截肢.
目前对DFU和CTLI的治疗方法存在局限性,这凸显了对替代方法的需求.

研究的目的:

为患有DFU和CTLI的患者提供细胞治疗作为截肢的替代方案.
为了确定细胞治疗干预的最佳时间框架.
评估先进治疗药物 (ATMP) 在预防截肢方面的安全性和有效性.

主要方法:

使用自主单核细胞 (MNCs) 和自主和异性介质细胞 (MSCs) 两种细胞.
向没有选择的关键四肢缺血症患者进行细胞治疗.
监测治疗效果,包括神经病变缓解,组织再生和愈合.

主要成果:

细胞治疗显示出愈的显著加速.
治疗导致血管和组织的再生.
没有报告严重的副作用,这表明了有利的安全性.
细胞疗法在预防肢体截肢方面被证明是有效的.

结论:

使用MNC和MSC的细胞疗法是DFU和CTLI的安全有效治疗方法.
ATMPs为截肢提供了一个可行的替代方案,显著改善了患者的治疗结果.
这种方法有可能减少下肢截肢的全球负担.

关键词:

关键威胁四肢缺血症关键威胁四肢缺血症在MSC中,MSC是MSC.截肢是一种截肢.卡尔科特的脚的脚.糖尿病患者的糖尿病脚足部足部足部足部足部足部介质细胞层层细胞.

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