在吸烟者的结膜组织样本中,洗眼抑制了 ангиотензин转化酶2的调节
Hiroshi Fujishima1,2, Hiroyuki Yazu1,2, Eisuke Shimizu2
1Department of Ophthalmology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan.
International journal of molecular sciences
|December 23, 2023
概括
吸烟者具有较高的血管酶转化酶2 (ACE2) 表达,增加了SARS-CoV-2的易感性. 眼睛冲洗显著降低了ACE2蛋白水平,表明它可能会降低感染风险.
科学领域:
- 眼科医生 眼科 眼科
- 病毒学 病毒学
- 肺部病理学 肺部病理学
背景情况:
- 眼睛表面表达血管酶转化酶2 (ACE2),这是SARS-CoV-2的受体.
- 吸烟是已知的呼吸道感染的危险因素,但其对眼睛ACE2表达和SARS-CoV-2易感性的影响尚不清楚.
研究的目的:
- 调查烟草吸烟是否会增加眼睛的ACE2表达,可能会增加SARS-CoV-2的易感性.
- 评估眼睛冲洗在降低眼睛ACE2水平和减轻感染风险方面的有效性.
主要方法:
- 使用RT-PCR和ELISA对照吸烟者和非吸烟者的ACE2基因和蛋白质表达的前性研究.
- 在参与者的子集中,在30秒眼睛冲洗之前和之后收集的眼和结膜样本.
主要成果:
- 与非吸烟者相比,吸烟者表现出明显更高的结膜ACE2基因表达 (p=0.003).
- 眼样本中的ACE2蛋白水平在眼睛冲洗后显著降低 (p=0.001).
- 在吸烟者的ACE2mRNA和蛋白质水平之间观察到较弱的相关性 (r=0.49).
结论:
- 眼睛表面细胞容易受到SARS-CoV-2感染.
- 吸烟可能会增加SARS-CoV-2感染的风险,原因是眼部ACE2表达升高.
- 眼睛冲洗可以作为防止眼睛病毒进入的保护措施.
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