周围感染的严重程度通过微依赖和独立机制对小鼠的大脑功能产生不同影响
Yen-Phung Le1,2, Kozo Saito1,2, Bijay Parajuli1,2
1Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Japan.
International journal of molecular sciences
|December 23, 2023
概括
周围感染会根据严重程度不同地影响大脑功能. 轻微的感染会使中风损伤恶化,而严重的感染会保护它,涉及不同的质细胞机制.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 外周感染和炎症会影响大脑功能.
- 质细胞,特别是微质细胞,与神经炎症有关.
- 外围感染严重程度对质细胞激活和脑损伤的确切作用尚不清楚.
研究的目的:
- 研究不同程度的外周感染对大脑功能和损伤的差异性影响.
- 阐明微质依赖和独立机制在这些影响中的作用.
主要方法:
- 使用不同持续时间的脂多糖化物 (LPS) 挑战 (1天和4天) 诱导外围感染.
- 中脑动脉阻塞 (MCAO) 模型用于评估脑损伤.
- 使用殖民地刺激因子-1受体 (CSF1R) 抗剂的微细胞枯竭.
- 对外围免疫细胞和微质的RNA测序的分析.
主要成果:
- 急性轻症感染 (1天LPS) 通过涉及外围免疫细胞的微质独立机制加剧了MCAO损伤.
- 严重感染 (4天LPS) 通过微质依赖机制保护MCAO损伤.
- 在两个感染组中都观察到微质激活.
- RNA测序揭示了4天LPS组微质中的抗炎和神经保护因素.
结论:
- 周围感染的严重程度决定了它对脑损伤的影响,导致恶化或保护.
- 微质的参与对于严重的外围感染的保护作用至关重要,但对于轻度感染的恶化而言却不至关重要.
- 这些发现强调了外周炎症,质细胞和脑损伤结果之间的复杂相互作用.
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