微波辅助的形成的Pterostilbene的Ternary包容复合物
Yousef A Bin Jardan1, Abdul Ahad1, Mohammad Raish1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2023
概括
微波技术创建了一个用β-cyclodextrin和Pluronic F-127的甲 (PTS) 三元包容复合体 (TIC). 这增强了PTS溶解性和抗氧化活性,提高了其潜在的生物可用性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 固醇 (PTS) 是一种具有有限的水溶性和口服生物利用性的天然植物毒素.
- 提高PTS溶解度对于提高其治疗疗效至关重要.
- 三级包容综合体 (TICs) 为药物输送提供了一个有前途的战略.
研究的目的:
- 使用微波技术准备一个PTS-TIC.
- 以其物理,化学和溶解特性来描述PTS-TIC.
- 为了评估准备好的PTS-TIC的抗氧化活性.
主要方法:
- 使用微波技术与β-cyclodextrin (βCD) 和Pluronic F-127 (PLF) 制备PTS-TIC.
- 使用DSC,FTIR,NMR,XRD和SEM进行表征.
- 溶解研究和抗氧化活性测定.
主要成果:
- 阶段溶解性研究显示,PTS水溶性增加了6.72倍.
- 从PTS-TIC中释放的PTS显著改善,在1小时内释放了74.03%.
- 鉴定证实了βCD腔内的PTS封装.
- 与自由PTS相比,PTS-TIC表现出更高的抗氧化活性.
结论:
- 微波技术是制备PTS-TIC的有效方法.
- 开发的PTS-TIC显著提高了PTS溶解度和抗氧化活性.
- 这种方法有可能提高PTS和类似的多化合物的生物可用性.
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