相关实验视频
Updated: Jul 7, 2025

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.7K
利西卡明降低了蛋白激酶B (AKT) 的激活,并促进了无塑性甲状腺癌的缩
Mariana Teixeira Rodrigues1,2,3, Ana Paula Picaro Michelli1,3, Gustavo Felisola Caso1,3
1Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo-UNIFESP, São Paulo 04021-001, Brazil.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2023
概括
西卡明是一种植物性类化合物,对侵袭性厌塑性甲状腺癌 (ATC) 是有前途的. 它有效地降低了癌细胞活力和诱导细胞死亡,提供了潜在的新治疗途径.
科学领域:
- 在瘤学瘤学.
- 自然产品化学 自然产品化学
- 细胞生物学 细胞生物学
背景情况:
- 无塑性甲状腺癌 (ATC) 是一种高度攻击性的甲状腺癌 (TC) 亚型,患者的生存率很低.
- 目前的TC治疗有局限性,包括严重的副作用和低生存率.
- 作为其他癌症中细胞毒性的已知天然化合物,如lysicamine,代表着尚未开发的治疗潜力.
研究的目的:
- 为了研究西卡明对乳头癌细胞和甲状腺癌细胞的抗瘤作用.
- 阐明lysicamine在这些癌细胞中诱导的细胞死亡机制.
主要方法:
- 用lysicamine治疗乳头癌细胞 (BCPAP) 和腺癌细胞 (HTH83,KTC-2).
- 评估细胞活力,运动性和殖民地形成.
- 对细胞死亡途径的分析,包括酶和亡.
- 在形预测lysicamine标蛋白.
主要成果:
- 在测试的甲状腺癌细胞中,lyscamine显著降低了细胞活力,运动性和殖民地形成.
- 观察到细胞死亡独立于细胞亡,有证据表明细胞亡.
- 西卡明治疗导致亡的增加,并抑制了AKT的激活.
- 在分析中,MAPK和TGF-β信号通路被认为是潜在的目标.
结论:
- 利西卡明对抗甲状腺癌细胞具有显著的抗瘤作用.
- 该化合物通过一种涉及AKT抑制和亡的机制诱导细胞死亡,独立于亡和活性氧物种.
- 利西卡明显示出作为治疗形甲状腺癌的新疗法药物的潜力.
相关概念视频
The Intrinsic Apoptotic Pathway
6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
167
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
167
Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K

