开发一种基于热降解特性的新型支气管扩展器蒸汽药物输送系统
Mariam Chaoui1, Emmanuelle Fischer1, Sophie Perinel-Ragey1,2
1Mines Saint-Etienne, Université Jean Monnet Saint-Etienne, INSERM, Sainbiose U1059, Centre CIS, F-42023 Saint-Etienne, France.
蒸汽药物输送系统 (VDDS) 可以有效地输送像terbutaline这样的支气管扩展剂. 这项研究表明,特定的电子液体配方和蒸汽技术可以实现与传统雾化器和吸入器相比的剂量等价性.
科学领域:
- 制药科学 制药科学
- 呼吸系统医学 呼吸系统医学
- 药物输送系统 药物输送系统
背景情况:
- 传统的支气管扩展剂输送方法包括喷气式雾化器,压力计量剂量吸入器 (pMDI) 和干粉吸入器 (DPI).
- 蒸汽药物输送系统 (VDDS) 提供了一种新的气溶药物输送方法,但它们对支气管扩展剂的有效性需要研究.
研究的目的:
- 通过使用不同的VDDS来调查支气管扩展剂的输送.
- 为了确定与临床雾化器和吸入器相比,VDDS的剂量等价性.
- 为了确定最佳的支气管扩展剂药物和vaping技术,以提供有效的交付.
主要方法:
- 三种支气管扩展剂 (terbutaline,salbutamol半硫酸盐,ipratropium化物) 被配制成电子液体.
- 两个VDDS (JUUL,GS AIR 2) 进行了药物输送测试.
- 使用高性能液态染色学 (HPLC) 进行了药物定量.
- 使用下一代冲击器 (NGI) 测量了颗粒大小分布.
主要成果:
- 在两种VDDS中,terbutaline被确定为支气管扩展剂的最佳活性药物成分 (API).
- GS AIR 2 装置提供了20.05 ± 4.2 μg / puff 的特布他林,而 JUUL 则提供了2.98 ± 0.52 μg / puff.
- 输送的剂量达到与喷气式雾化剂和DPI相似的剂量等效,具有合理的输送持续时间.
结论:
- 在使用适当的配方,vaping技术和特定药物时,VDDS可以有效用于支气管扩展剂的输送.
- 药物选择至关重要,这取决于热降解特性.
- 这项研究提供了第一个证据,证明了在特定条件下蒸汽支气管扩展剂的有效性.
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