生物潜力和生物可访问性封装的黄素成乙烯基三甲基化改性纤维素纳米晶体
Francisca Casanova1, Carla F Pereira1, Alessandra B Ribeiro1
1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2023
概括
用 cetyltrimethylammonium化物 (CNC-CTAB) 修改的纤维素纳米晶体有效地封装黄素,增强其抗氧化,抗炎和抗菌特性,改善肠道健康.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 黄素是一种天然的化合物,在体外表现出显著的生物活性.
- 黄素的体内疗效受到生物可访问性和生物可用性差的限制.
- 用 cetyltrimethylammonium化物 (CNC-CTAB) 修饰的纤维素纳米晶体显示出对黄封装的希望.
研究的目的:
- 为了评估黄素在CNC-CTAB结构中封装的生物效应.
- 评估封装的黄素的抗氧化,抗炎和抗菌性质.
- 为了研究CNC-CTAB-curcumin系统的释放特征和肠道透性.
主要方法:
- 在CNC-CTAB中封装黄素.
- 通过测量活性氧物种 (ROS) 减少来评估抗氧化活性.
- 通过量化肠道细胞中细胞因子的产生来评估抗炎作用.
- 针对 *Campylobacter jejuni* 的抗菌检测.
- 在模拟消化条件下对黄素释放的分析.
- 对肠表皮相互作用和透性的研究.
主要成果:
- 封装的黄素显示出显著的抗氧化和抗炎性质,减少ROS和细胞因子的产生.
- 在CNC-CTAB的输送系统中显示出对*Campylobacter jejuni*的抗菌活性.
- 该系统保护黄素免受降解,并促进其与肠道上皮的相互作用.
- 黄素释放概况和肠道透性受到CNC-CTAB载体的有利调节.
结论:
- CNC-CTAB是一种有前途的载体系统,可提高黄素的生物可访问性和生物可用性.
- 封装的黄素显示出减轻肠道炎症和感染的潜力.
- 这种纳米技术方法可以改善黄素的体内治疗应用.
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