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使用迷你使用室系统的肠道吸收和新陈代谢的同时预测方法

Satoshi Kondo1,2, Masateru Miyake3

  • 1Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 460-10 Kagasuno Kawauchi-cho, Tokushima 771-0192, Japan.

Pharmaceutics
|December 23, 2023
PubMed
概括

使用人类和动物肠道组织的新型迷你使用室方法可以同时预测药物的肠道吸收和新陈代谢. 这种运输指数 (TI) 方法提供了比传统的基于细胞的药物开发模型更准确的评估.

关键词:
使用室使用室.胃肠道的生理状况 胃肠道的生理状况肠道吸收 肠道吸收肠道代谢 肠道代谢代谢物形成指数 (MFI)预测 预测 预测 预测交通运输指数 (TI)

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