口膜:当前的创新和新兴趋势
Shery Jacob1, Sai H S Boddu2,3, Richie Bhandare2,3
1Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates.
Pharmaceutics
|December 23, 2023
概括
口腔可分散膜 (ODF) 为药物输送提供了一个多功能平台,配方,3D打印和纳米粒子集成方面的进步提高了各种药物的效率和患者遵守性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 口腔可分散膜 (ODF) 是设计用于快速口腔溶解的聚合物膜,可有效地提供局部和/或全身药物.
- 最近的创新重点是优化ODF配方组件,制备方法和集成先进技术.
研究的目的:
- 审查口腔可分散膜 (ODF) 作为药物输送系统的多方面的方面.
- 突出最近的进展,评估方法,临床应用和ODF技术的未来方向.
主要方法:
- 关于ODF配方,制备技术 (溶剂造,3D打印) 和纳米粒子集成的综合文献综述.
- 对体外评估方法,临床试验,销售产品和专利环境的分析.
- 探索以患者为中心的方法和用于增强药物透的新型辅助剂.
主要成果:
- ODF在配方和制备方面提供了灵活性,3D打印可以实现多层结构和多种复合材料的结合.
- 纳米粒子集成显著提高了口服药物递送效率.
- 目前正在进行的研究重点是患者友好的属性,如口味掩饰和易于使用,以及个性化的配方.
结论:
- 开放式药物输送系统 (ODF) 是一个快速发展的药物输送系统,具有改善患者服药性和扩大治疗选择的巨大潜力.
- 对新型辅助剂的进一步研究对于通过ODFs传递具有挑战性的分子,如蛋白质和寡核酸至关重要.
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