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相关概念视频

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Drugs that Stabilize Microtubules01:15

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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相关实验视频

Updated: Jul 7, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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结肠直肠癌干细胞和向的代理商

Haobin Zhao1,2, Ruining Han3, Zhankun Wang4

  • 1Department of General Practice, People's Hospital of Longhua, 38 Jinglong Jianshe Road, Shenzhen 518109, China.

Pharmaceutics
|December 23, 2023
PubMed
概括
此摘要是机器生成的。

向结直肠癌干细胞 (CR-CSCs) 对于克服治疗耐药性和预防转移至关重要. 本综述详细介绍了CR-CSC特征,调节途径以及改善结直肠癌治疗的新兴治疗策略.

关键词:
一个Lgr55,一个Lgr5没有信号通路.结肠直肠癌的干细胞是什么单细胞欧米克技术的技术.

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科学领域:

  • 在瘤学瘤学.
  • 干细胞生物学 干细胞生物学
  • 分子生物学分子生物学

背景情况:

  • 癌症干细胞 (CSCs) 驱动瘤的进展,转移和治疗抵抗.
  • 结肠直肠癌 (CRC) 仍然是一个重大的全球卫生挑战,死亡率高.
  • 大肠直肠癌干细胞 (CR-CSCs) 是CRC进展和复发的关键驱动因素.

研究的目的:

  • 提供关于结直肠癌干细胞 (CR-CSCs) 的全面概述.
  • 要总结CR-CSCs的起源,生物标志物,种植和研究技术.
  • 审查针对CR-CSC的信号通路和治疗策略.

主要方法:

  • 对CR-CSC研究的文献综述.
  • 关于CR-CSC识别和种植方法的摘要.
  • 对调节CR-CSC干度的信号通路 (Wnt,JAK/STAT3,Notch,Hh) 的分析.
  • 审查当前和新兴的抗CR-CSC药物和疗法.

主要成果:

  • CR-CSCs具有自我更新和分化能力,有助于转移和耐药性.
  • 像Wnt,JAK/STAT3,Notch和Hh这样的关键信号通路对于CR-CSC干性至关重要.
  • 各种生物标志物和研究技术有助于CR-CSC的识别和研究.
  • 新兴药物针对特定的途径和监管机构,以消除CR-CSC.

结论:

  • 向CR-CSC提供了一种有前途的策略,可以抑制转移,提高治疗疗效,并减少结直肠癌的复发.
  • 了解CR-CSC生物学和调节途径对于开发新型治疗剂至关重要.
  • 本综述提供了对当前抗CR-CSC药物和潜在的未来治疗方法的见解.