针对人道主义反应的疫苗接种指南的系统审查
Lauren E Allison1, Mervat Alhaffar1,2, Francesco Checchi1
1Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
人道主义疫苗接种指南丰富,但缺乏证据,伦理考虑,以及"零剂量"儿童和受影响人口的纳入. 对于HPV等特定疫苗存在差距,需要紧急关注.
科学领域:
- 全球健康 全球健康
- 疫苗学 疫苗学 疫苗学
- 人道主义应对行动
背景情况:
- 在人道主义环境中提供疫苗需要严格的证据分析.
- 现有的针对危机受影响人口的疫苗接种指南是广泛的,但可能有局限性.
研究的目的:
- 在人道主义背景下系统地绘制和批判性地评估针对疫苗可预防疾病的规范性疫苗接种指南.
- 识别当前指南中关于证据纳入,伦理考虑和特定人群或疫苗的空白.
主要方法:
- 从人道主义行动者的网站和数据库 (全球卫生,Embase) 中对指导文件 (2000-2022) 的系统审查.
- 以英语和法语进行搜索,包括选参考列表.
- 在线调查向人道主义疫苗接种专业人员传播.
主要成果:
- 确定了48份符合条件的指导文件,主要来自世界卫生组织,针对幼儿.
- 批判性评估表明受影响人群的纳入不足,指导方针制定中的严谨性有限.
- 针对特定疫苗 (如黄热病,霍乱,HPV) 和伦理考虑,发现了信息缺口.
结论:
- 虽然大量,但人道主义疫苗接种指南需要改进证据整合,伦理框架,并解决"零剂量"儿童和受影响的人口.
- 需要对非普遍推的疫苗和HPV做出具体建议.
- 解决这些差距对于在危机环境中有效提供疫苗至关重要.
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