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在西西里完全或增强mRNA接种疫苗的受试者中,SARS-CoV-2再感染的低风险:使用真实世界的数据进行基于人口的研究

Laura Maniscalco¹, Dario Genovese¹, Barbara Ravazzolo²

¹Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro" (PROMISE), University of Palermo, Via del Vespro 133, 90127 Palermo, Italy.

|December 23, 2023

概括

接种COVID-19疫苗显著降低了SARS-CoV-2再感染的风险,特别是在增强剂量时. 诸如年龄,性别和先前住院等因素也会影响再感染率,老年人表现出更强的保护性.

科学领域:

流行病学流行病学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

由于免疫力下降和新的病毒菌株,SARS-CoV-2的再感染受到驱动.
了解影响再感染的因素对于公共卫生战略至关重要.

研究的目的:

在意大利西西里研究性别,年龄,COVID-19疫苗接种,先前住院和SARS-CoV-2再感染之间的相关性.

主要方法:

基于人口的回顾性队列研究,使用区域疫苗接种和健康监测数据.
考克斯回归分析用于计算重新感染的调整危险比率 (adj-HR).

主要成果:

与未接种疫苗的人相比,完全接种疫苗 (adj-HR:0.43) 和增强剂量 (adj-HR:0.41) 显著降低了再感染风险.
男性 (adj-HR:0.75) 和以前住院的人 (adj-HR:0.78) 的再感染风险较低.
较老的成年人 (60岁以上) 显示出统计保护,而30-49岁的人有更高的风险. 在Omicron波期间,再感染更为常见.

结论:

接种COVID-19疫苗是防止SARS-CoV-2再感染的关键公共卫生工具,特别是针对Omicron变种.
年龄,性别和先前住院是影响再感染风险的重要因素.
在老年人和住院患者中,再感染风险较低表明这些群体的保护行为或免疫力得到了增强.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.西西里西西里西西里流行病学流行病学基于人口的分析.重新感染的情况.

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