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怀孕期间的COVID-19疫苗接种:对孕产妇和新生儿的微RNA概况进行试点研究

Wei-Chun Chen^1,2,3,4,5, Shu-Yu Hu¹, Ching-Fen Shen⁶

¹Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan.

|December 23, 2023

概括

接种COVID-19疫苗会改变孕妇和新生儿的微RNA (miRNA) 概况. 较高的疫苗剂量与特定miRNA水平的显著变化相关,影响母亲和胎儿的分子通路.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

怀孕期间接种COVID-19疫苗对于保护母亲和婴儿至关重要.
了解疫苗对母胎分子形状的影响至关重要.

研究的目的:

为了调查不同剂量的COVID-19疫苗接种后,孕妇和新生儿的微RNA (miRNA) 概况变化.
探索这些miRNA变化与特定分子通路的关联.

主要方法:

试点研究涉及五名孕妇及其新生儿.
使用miRNA PanelChip分析系统对母体血液 (MB) 和新生儿带血液 (CB) 的分析.
识别和量化九个不同的miRNAs.

主要成果:

在MB和CB两种疫苗剂量中观察到miR-451a和miR-1972的显著下调.
与四剂量相比,miR-486-5p,miR-451a和miR-1972在两剂量组下调.
增加疫苗剂量与减少miR-223-3p和增加miR15a-5p,miR-16-5p和miR-423-5p相关.
特定的miRNAs (miR-451a,miR-1972,miR-423-5p) 与PI3K-Akt,神经营蛋白信号传递和皮质醇合成途径相关.

结论:

升级COVID-19疫苗剂量显著影响孕妇和新生儿的miRNA概况.
这些miRNA变化可能反映了潜在的免疫反应机制.
疫苗接种深深地影响了母胎二合体中的多种分子过程.

关键词:

关于COVID-19疫苗的使用情况现代的现代的瑞生物科技公司 (Pfizer BioNTech) 的这就是SARS-CoV-2病毒.这是带血,带血.这是一个小RNARNA.新生儿新生儿新生儿新生儿怀孕怀孕怀孕怀孕怀孕怀孕

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...