新诊断的儿科炎性肠病中低骨矿物质密度的危险因素
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1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Nutrients
|December 23, 2023
概括
儿童炎症性肠病 (IBD) 即使在诊断时也与低骨矿物质密度 (BMD) 有关. 较低的BMI和较长的症状持续时间是IBD儿童骨健康降低的关键风险因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 胃肠病学 胃肠病学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 全球炎症性肠病 (IBD) 发病率正在上升,通常在儿童和青少年中被诊断出来.
- 儿科IBD影响生长,青春期,营养和骨健康,需要仔细监测.
- 在亚洲儿科IBD群体的骨结局上存在有限的研究.
研究的目的:
- 确定韩国儿童和青少年新诊断出IBD的低骨矿物密度 (BMD) 的患病率.
- 在这个儿科IBD队列中确定与低BMD相关的风险因素.
- 为了在诊断时确定BMD和临床/实验室标志物之间的相关性.
主要方法:
- 包括51名新诊断克罗恩病 (CD) 或性结肠炎 (UC) 的患者 (10-18岁).
- 双能X射线吸收仪 (DXA) 用于腰椎 (LSBMD) 和大腿骨 (FBMD) 骨矿物质密度的Z-分数.
- 低BMD定义为年龄和性别匹配的Z-score<-1.0;进行回归分析以确定危险因素.
主要成果:
- 平均LSBMD和FBMDZ分数分别为-0.11±1.24和-0.58±1.38. 这两种分数的平均值分别为-0.11±1.24和-0.58±1.38
- 超过50%的Z分数在0和-1.0之间;7.8% (LSBMD) 和18% (FBMD) 的Z分数<-2.0.
- 较低的BMI Z-score (<-0.93),较长的症状持续时间和较高的血清水平是低BMD的显著风险因素.
结论:
- 儿童IBD患者中很大一部分在诊断时表现出低BMD,在治疗之前.
- 低BMI (OR 31.97-41.45) 是小儿IBD中低BMD的强有力的预测因素.
- 从诊断到预防儿科IBD患者的二次骨质疏松症,例行骨健康监测至关重要.
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