麦可以通过维护肠道屏障和调节Keap1-Nrf2轴来缓解酸盐诱导的大肠炎
Zhong-Hao Ji1,2, Wen-Yin Xie1, Pei-Sen Zhao1
1Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
麦 (OPs) 在预防炎症性肠病 (IBD) 中表现有前途. OP保护肠道屏障并调节关键信号通路,为IBD提供潜在的饮食干预.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 炎症性肠病 (IBD) 的流行率不断上升,需要有效的预防策略.
- 饮食干预措施,特别是那些利用像麦这样的功能性食品成分的干预措施,正在引起人们的注意.
- 麦是一种丰富的蛋白质来源,产生具有潜在健康益处的生物活性.
研究的目的:
- 为了研究麦 (OPs) 对硫酸盐 (DSS) 诱导的急性结肠炎的保护作用.
- 阐明OP在肠道炎症中的作用的潜在分子机制.
- 在OP中识别潜在的生物活性序列,负责其治疗效果.
主要方法:
- 使用DSS管理建立一种小鼠急性结肠炎模型.
- 在体外评估使用Caco-2细胞模型来评估肠道屏障完整性.
- 对OP的物理化学表征,包括分子重量分布和形状.
- 通过OPs对Keap1-Nrf2信号轴调制的分析.
主要成果:
- 在小鼠中,OP的干预显著缓解了DSS诱导的大肠炎的症状.
- 物理化学分析显示,OP主要低于5kDa,由266个组成.
- 运营商证明了对Keap1-Nrf2信号轴的监管影响.
- 酸WGVGVRAERDA被确定为一种潜在的主要生物活性成分.
结论:
- 麦酸有效地减轻DSS诱导的大肠炎,通过保持肠道屏障的完整性.
- OPs调节Keap1-Nrf2信号通路,有助于它们的抗炎作用.
- 这些发现支持使用OP作为预防炎症性肠病的食补充剂.
更多相关视频
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Renewal of Intestinal Stem Cells
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
