相关实验视频
Updated: Jul 7, 2025

06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
35.2K
营养供应对全球前列腺癌风险的影响
Jinjiang Jiang1, Jie Yang1, Bo Chen1
1Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China.
Nutrients
|December 23, 2023
概括
全球前列腺癌的发病率与动物蛋白摄入量和饮食模式有显著的相关性,特别是在发达国家. 较低的癌症发病率与较高的谷物,根和根茎的消费量有关.
科学领域:
- 营养流行病学 营养流行病学
- 全球健康 全球健康
- 在瘤学瘤学.
背景情况:
- 前列腺癌是全球重要的健康问题.
- 饮食因素越来越被认为是癌症风险的潜在调节因素.
- 了解营养供应与前列腺癌发病率之间的关系对于公共卫生战略至关重要.
研究的目的:
- 调查国家营养供应与前列腺癌发病率之间的全球联系.
- 为了确定与全球前列腺癌率相关的特定饮食成分.
- 根据国家一级的社会经济因素,探索这种关联的变化.
主要方法:
- 利用来自150个国家的粮农组织营养供应 (总蛋白质,动物蛋白质,脂肪,蛋白质比例,谷物/根/根茎) 的数据.
- 来源前列腺癌发病率数据来自2019年全球疾病负担研究 (GBD2019).
- 根据社会人口统计指数 (SDI) 分层的就业相关性,回归分析和子组分析.
主要成果:
- 前列腺癌发病率与平均总蛋白 (APS),动物蛋白 (AAPS),脂肪 (AFS),动物蛋白/总蛋白比 (ATR) 以及谷物,根和根茎 (CR) 的平均供应有显著的相关性.
- 经过对混因子进行调整后,回归分析揭示了AAPS,ATR和CR与前列腺癌年龄标准化发病率 (ASIR) 之间的显著关联.
- 没有发现APS和AFS与ASIR有显著的关联. 亚组分析表明,在SDI中等至高的国家中,关联更强,但在SDI低和中低的国家中没有.
结论:
- 全球前列腺癌的发病率与较高的动物蛋白摄入量和较低的谷物,根和根茎摄入量显著相关.
- 饮食模式,特别是富含动物蛋白质的饮食模式,与前列腺癌发病率的增加有关.
- 营养供应与前列腺癌发病率之间的关联在经济发达国家更为明显.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Disorders of the Male Reproductive System
422
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
422
Cancer Survival Analysis
355
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
355
Key Elements for Plant Nutrition
18.8K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
18.8K

