登革热病毒的亚基因组病毒RNA
Yi Liu1, Wuxiang Guan1,2, Haibin Liu1,2
1Hubei Jiangxia Laboratory, Wuhan 430200, China.
Viruses
|December 23, 2023
概括
亚基因组黄病毒RNAs (sfRNAs) 是稳定的病毒RNA片段,可以抑制宿主防御. 本综述涵盖了它们的产生,结构和在弗拉维病毒病原和传播中的作用.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 在RNA生物学,RNA生物学.
背景情况:
- 病毒感染产生亚基因组病毒RNAs (sfRNAs).
- sfRNAs起源于病毒的3'未翻译区域 (3' UTR).
- 由于特定的RNA结构 (xrRNAs),它们对宿主5'-3'外核糖酶降解具有抗性.
研究的目的:
- 审查登革热病毒sfRNAs (DENVsfRNAs) 的生物发生,结构和功能.
- 探索DENV sfRNAs在病毒干扰和致病性中的作用.
主要方法:
- 文献综述总结了关于DENV sfRNAs的现有研究.
- 分析与xrRNA和子结构 (DBs) 相关的结构和功能数据.
主要成果:
- 登革热病毒产生3-4个不同的sfRNA物种.
- xrRNAs形成环状结构,抑制宿主外核酶Xrn1.1.
- DENV sfRNA 与病毒和宿主蛋白相互作用,调节病原性,适应性和传播.
结论:
- DENV sfRNAs是弗拉维病毒感染结果的关键调节者.
- 了解sfRNA结构和功能对于开发抗病毒策略至关重要.
- sfRNAs影响病毒病原性,复制和传播.
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