在使用不同COVID-19疫苗接种疫苗后,对SARS-CoV-2进行口服IgA反应的开发
Irene Soffritti1, Maria D'Accolti1, Francesca Bini1
1Department of Chemical, Pharmaceutical and Agricultural Sciences, and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA), Section of Microbiology, University of Ferrara, 44121 Ferrara, Italy.
Viruses
|December 23, 2023
概括
这项研究发现,大多数接种疫苗的人都产生了粘膜免疫反应,由唾液免疫球蛋白A (IgA) 表示,该免疫反应与血清免疫球蛋白G (IgG) 对抗SARS-CoV-2的水平相关. 唾液IgA监测可能有助于未来的疫苗开发和管理策略.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 粘膜免疫反应对于控制像SARS-CoV-2这样的感染至关重要,这种感染主要通过粘膜组织进入.
- 在SARS-CoV-2感染个体中观察到唾液免疫球蛋白A (IgA),与COVID-19症状严重程度相反相关.
- 关于不同SARS-CoV-2疫苗如何在病毒进入部位诱导局部IgA反应的数据有限.
研究的目的:
- 评估在补充疫苗接种后的唾液中抗SARS-CoV-2 IgA的存在和水平.
- 为了比较由不同的疫苗组合引起的IgA反应,包括mRNA-1273 (Moderna),BNT162b2 (Pfizer-BioNTech) 和Vaxzevria (AstraZeneca).
主要方法:
- 在95名接种了疫苗的受试者中测量了唾液IgA标位,这些受试者接受了各种疫苗组合和强剂量.
- 血清抗SARS-CoV-2IgG标位也被评估为相关性.
- 进行了统计分析,以比较不同类型和组合疫苗之间的反应.
主要成果:
- 粘膜反应,检测为唾液IgA,在93.7%的接种疫苗的人群中存在 (平均标位:351.5±31.77U/mL).
- 唾液IgA标位与血清抗SARS-CoV-2IgG标位有很强的相关性 (p < 0.0001).
- 在疫苗类型之间没有发现IgA反应的统计学上显著差异,尽管在BNT162b2初级剂量后,在mRNA-1273增剂时观察到略高的标位.
结论:
- 对SARS-CoV-2的疫苗接种有效地诱导了唾液IgA粘膜反应.
- 监测唾液IgA是疫苗设计和监测策略的宝贵工具.
- 这些发现支持疫苗注射和增强的潜在新途径.
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