骨矿物质密度和椎骨分数在艾滋病毒感染妇女的绝经期间的变化
Jovana Milic1,2, Stefano Renzetti3, Denise Morini4
1Modena HIV Metabolic Clinic, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Viruses
|December 23, 2023
概括
在更年期期间,艾滋病毒感染妇女的骨矿物质密度 (BMD) 和椎骨分数 (TBS) 显著下降. 更年期的过渡期是评估骨健康和WWH风险因素的关键时期.
科学领域:
- 骨生物学和新陈代谢
- 艾滋病毒/艾滋病研究研究
- 更年期研究的研究.
背景情况:
- 骨矿物质密度 (BMD) 和脊椎骨分数 (TBS) 是骨健康的关键指标.
- 艾滋病毒感染女性 (WWH) 可能会经历加速的骨质损失,特别是在更年期.
- 了解WWH接受不同抗逆转录病毒疗法 (ART) 的骨密度变化对于管理骨健康至关重要.
研究的目的:
- 描述患有艾滋病毒 (WWH) 的妇女在绝经前和绝经后阶段的骨矿物质密度 (BMD) 和椎骨分数 (TBS) 轨迹.
- 研究不同抗逆转录病毒疗法 (ART) 对WWH骨密度变化的影响.
- 为了确定与骨矿物质密度 (BMD) 和椎骨分数 (TBS) 相关的风险因素,WWH的变化.
主要方法:
- 一项观察性,纵向性,回顾性研究,涉及202名艾滋病毒感染妇女 (WWH).
- 根据STRAW+10标准定义的四个更年期 (生殖期,更年期过渡期,早期和晚期更年期) 的DEXA评估对BMD和TBS测量的分析.
- 混合效应模型被用于估计BMD和TBS轨迹,以后向消除以确定显著的预测因素.
主要成果:
- 骨质疏松症和骨质疏松症的患病率从绝经前期到绝经后期在世界大战期间显著增加.
- 骨质硬化和TBS都显示在绝经前和绝经后期间显著下降.
- 在所有更年期阶段,骨质量下降,而TBS斜率没有显著变化,更年期过渡和生殖期之间显著下降.
结论:
- 随着时间的推移,艾滋病毒感染妇女的骨矿物质密度 (BMD) 和骨骨分数 (TBS) 显著下降.
- 更年期过渡期的特点是骨硬化和TBS的显著下降,这突显了其对骨健康评估的重要性.
- 在更年期过渡期间,临床医生应优先评估骨健康和可修改的风险因素.
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