孕产妇COVID-19血清变化 - - 怀孕第一和第三季度血清转化率与随后的产科并发症之间的比较:一项队列研究
Maria N Rayo1,2, Adriana Aquise1,2, Irene Fernandez-Buhigas1,2
1Department of Obstetrics and Gynecology, Hospital Universitario de Torrejón, Torrejón de Ardoz, 28850 Madrid, Spain.
Viruses
|December 23, 2023
概括
孕妇在怀孕期间出现了SARS-CoV-2感染率的增加,特别是在第三个三个月. 然而,在早期和晚期怀孕血清转换器之间,没有发现母亲或产科并发症的显著差异.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 孕妇面临呼吸道疾病的风险增加,包括COVID-19.
- 了解怀孕期间的SARS-CoV-2血清转化模式对于孕产妇和胎儿的健康至关重要.
- 感染时间 (第一季度与第三季度) 对怀孕结果的影响需要研究.
研究的目的:
- 为了确定整个怀孕期间的SARS-CoV-2血清转化率.
- 为了比较在第一季度与第三季度血清转换的妇女之间的孕产妇和产科并发症.
主要方法:
- 在西班牙马德里首次COVID-19高峰期间,对470名孕妇进行了观察性队列研究.
- 从第一和第三个三个月的IgA和IgG抗体对SARS-CoV-2IgA和IgG抗体的储存血清样本的分析.
- 每月对血清阳性妇女进行随访,直到分娩.
主要成果:
- 在第一季度检测到6.6%的SARS-CoV-2抗体,在第三季度检测到14.0%.
- 从第一个到第三个三个月的感染率显著增加 (p = 0.003).
- 在第一季度与第三季度血清转换的妇女之间,在产妇或产科并发症方面没有发现显著差异.
结论:
- 随着妊娠的进展,怀孕与SARS-CoV-2感染的风险增加有关.
- 怀孕期间血清转换时间似乎没有影响这一队列中的孕产妇或产科并发症.
- 需要进一步的研究才能充分阐明妊娠期COVID-19的长期影响.
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