吸烟,酒精摄入和扭矩病毒在稳定的脏移植接受者中
Caecilia S E Doorenbos1, Jip Jonker1, Jiasi Hao2
1Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Viruses
|December 23, 2023
概括
移植接受者 (KTRs) 的扭矩病毒 (TTV) 负载受生活方式的影响. 吸烟和高酒精摄入量与较低的TTV水平有关,影响免疫抑制指南.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 扭矩病毒 (TTV) 在移植接受者 (KTRs) 中非常普遍.
- TTV病毒载量与免疫状况相关,可以指导免疫抑制疗法.
- 确定TTV负载决定因素对于优化KTR管理至关重要.
研究的目的:
- 调查吸烟,饮酒和KTRs中的TTV负载之间的关联.
- 确定生活方式因素是否影响稳定移植患者的TTV水平.
主要方法:
- 666个稳定的KTR (移植后≥1年) 的截面研究.
- 血清TTV负荷通过PCR测量.
- 吸烟状况和酒精摄入量通过调查问卷评估,尿中的科提宁和乙基葡萄糖胺水平.
主要成果:
- 在82%的KTR中发现了可检测的TTV负载.
- 环素和塔克罗利斯的使用显示出与TTV负载的积极关联.
- 目前的吸烟和酒精摄入量 (>20克/天) 与TTV负载负相关,独立于其他因素.
结论:
- 吸烟和酒精摄入量是KTRs中TTV负载的显著负决定因素.
- 在使用TTV指导移植接受者的免疫抑制时,必须考虑这些生活方式因素.
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