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在帕金森病中,小和结构良好的主要幻觉的功能性大脑网络

Kyoungwon Baik¹, Yae Ji Kim^2,3, Mincheol Park^4,5

¹Department of Neurology, Anam Hospital, Korea University College of Medicine, Seoul, South Korea.

Movement disorders : official journal of the Movement Disorder Society

|December 23, 2023

概括

背部注意网络 (DAN) 功能障碍是帕金森病精神病进展的关键. 这项研究发现,小幻觉 (mH) 和大幻觉 (MH) 患者的静止状态网络连接发生变化.

科学领域:

神经科学是一个神经科学.
神经学神经学
精神病学是一个精神病学.

背景情况:

帕金森病 (PD) 精神病通常具有轻微幻觉 (mH) 和主要幻觉 (MH).
了解这些幻觉的神经支对于患者护理至关重要.

研究的目的:

在没有幻觉的PD患者 (PD-nH),有mH的PD患者 (PD-mH) 和有MH的PD患者 (PD-MH) 中调查静止状态网络 (RSN) 的差异.
确定与帕金森病幻觉严重程度相关的特定RSN.

主要方法:

在73名PD患者 (27 PD-nH, 23 PD-mH, 23 PD-MH) 中对RSN (DMN, ECN, DAN, VAN, VN) 的功能连接性分析.
在三个组中比较认知功能和RSN连接.
种子对种子分析,检查每个组内的互联网连接.

主要成果:

PD-MH组表现出较低的注意力和视觉空间功能得分.
在PD-MH组中观察到背部注意网络 (DAN) 内的连接性减少.
在幻觉PD患者中,默认模式网络 (DMN),执行控制网络 (ECN),腹部注意网络 (VAN) 和视觉网络 (VN) 的连接性发生变化.

结论:

背部注意力网络 (DAN) 功能障碍在帕金森病中从轻微幻觉到主要幻觉的进展中显得至关重要.
特定的RSN变化与PD患者幻觉的存在和严重程度相关.

关键词:

帕金森病的疾病.功能成像功能成像功能成像幻觉幻觉幻觉幻觉幻觉

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