基诺的安全性 基诺的安全性
J Barberán1, A de la Cuerda, M I Tejeda González
1José Barberán, Hospital Universitario HM Montepríncipe, Facultad HM Hospitales de Ciencias de la Salud, Universidad Camilo José Cela, Madrid, Spain. jose.barberan@ucjc.edu.
概括
诺基诺 (FQs),常见的抗生素,携带严重的,持久的副作用的风险,如肌破裂和大动脉动脉瘤. 本综述涵盖了这些威胁和替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 传染性疾病 传染性疾病
背景情况:
- 诺基诺 (FQs) 是一种被广泛处方的抗生素.
- 最初的试验表明耐受性很好.
- 市场营销后的研究显示了严重的不良影响.
研究的目的:
- 审查化诺的显著不良影响.
- 讨论关于FQs的监管警告.
- 探索其他治疗选择.
主要方法:
- 流行病学研究的文献综述.
- 监管机构通信的分析.
- 综合有关FQ相关毒性的信息.
主要成果:
- 与严重,持续的不良影响相关的FQs.
- 神经毒性和原降解是关键问题.
- 例如包括肌炎,破裂,大动脉动脉瘤,视网膜脱落.
结论:
- 诺基诺含有超出初步评估范围的重大风险.
- 监管机构已经发出警告.
- 应考虑治疗替代方案,以确保患者的安全.
相关概念视频
Imaging Studies for Cardiovascular System III: X-Ray
188
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
188
Radiological Investigation I: X-ray and CT
241
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
241
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
124
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
124
Renal Failure: Dose Adjustments
94
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
94
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
1.4K
Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
1.4K


