用拉曼光谱和化学计量工具对固体剂量形式的塞法列素进行定量分析
Nida Ghafoor1, Naeema Kanwal1, Haq Nawaz1
1Department of Chemistry, University of Agriculture Faisalabad, Faisalabad, Pakistan.
Drug development and industrial pharmacy
|December 23, 2023
概括
拉曼光谱有效地量化了制药配方中的塞法莱克辛. 这种非侵入性技术与部分最小方位回归 (PLSR) 分析相结合,可提供准确且快速的药物度测量.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 频谱学是一种光谱学.
背景情况:
- 拉曼光谱为制药分析提供了一种非侵入性,快速和可靠的方法.
- 精确量化药品活性成分 (API) 对于药品质量控制至关重要.
研究的目的:
- 评估拉曼光谱对药物配方中Cephalexin API的定性和定量分析的有用性.
- 探索多变量数据分析技术的应用,以进行增强的光谱解释.
主要方法:
- 用不同度的标准塞法列辛样品的制备.
- 使用主要组件分析 (PCA) 进行定性分析.
- 使用部分最小平方回归 (PLSR) 建模的定量分析.
主要成果:
- 通过PCA,PCA成功地区分了各种Cephalexin配方的光谱数据.
- 该PLSR模型显示了高预测效率 (R2 = 0.98) 的低误差 (RMSEC = 3.3953,RMSEP = 3.8972).
- 该PLSR模型准确地预测了未知样本中的Cephalexin度.
结论:
- 拉曼光谱与PLSR分析相结合,是一种强大而有效的工具,用于对诸如Cephalexin之类的药物进行定量分析.
- 这种方法为制药品质量控制提供了快速可靠的替代方案.
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