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同样纠的 #73: 狮子的头
Maya Muhanna1, Issac Lund1, Mark Bromberg2
1Medical College of Georgia at Augusta University, Augusta, GA, USA.
Amyotrophic lateral sclerosis & frontotemporal degeneration
|December 23, 2023
概括
狮子毛显示出潜在的神经保护作用,但缺乏足够的证据来治疗肌缩侧面硬化症 (ALS). 需要进一步研究ALS模型和临床试验,以确定疗效和安全性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统医学的传统医学.
背景情况:
- 狮子毛 (Hericium erinaceus) 是一种在传统亚洲和欧洲医学中使用的.
- 在临床前研究中,它表现出抗炎,神经保护和神经元生长促进的特性.
- 一项小型试验表明,轻度认知障碍的认知能力暂时有所改善,但这需要复制.
研究的目的:
- 审查目前关于神经退行性疾病中狮子毛的证据,特别是肌缩侧面硬化症 (ALS).
- 评估狮子的潜在作用机制和安全概况.
- 为了确定当前的数据是否支持其在ALS治疗中的使用.
主要方法:
- 关于狮子毛毛的研究文献综述,包括细胞模型,动物模型和人体试验.
- 分析与神经保护相关的已报告的作用机制.
- 评估安全数据和不良事件报告.
主要成果:
- 临床前数据表明神经退行性疾病相关的神经保护机制.
- 一个小型的人类试验表明,在轻度认知障碍中,暂时的认知益处.
- 没有研究在ALS细胞或动物模型中或在人类ALS患者中研究了狮子毛.
- 狮子毛在粉末/囊形式通常是安全的,但新鲜的使用导致了一例过敏反应病例.
结论:
- 目前的证据不足以支持Lion's Mane用于ALS治疗.
- 虽然临床前数据是有希望的,但对ALS模型和人体试验的严格研究是必不可少的.
- 建议进行进一步研究,以确定ALS患者的疗效和安全性.
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