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合成,晶体结构和生物活动的阿罗伊尔化二-m-基酸复合体

Wujiu Jiang¹, Pengfei Zhou¹, Le Chen¹

¹Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, 421008, Hunan, China.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

|December 23, 2023

概括

合成和表征了六种新的锡复合物. 与西斯相比,复合物2表现出更好的癌细胞增殖抑制,并通过间隔与DNA相互作用.

科学领域:

有机金属化学有机金属化学
协调化学协调化学
材料科学材料科学材料科学

背景情况:

有机蛋白化合物表现出多样化的生物活动.
阿洛基连接物提供了多功能协调模式.
锡复合物正在探索潜在的治疗应用.

研究的目的:

为了合成和描述新型的阿罗伊尔化二-m-基胺复合物.
研究这些复合物的结构,光谱和热性质.
评估合成的锡复合物的细胞毒性活性和DNA结合相互作用.

主要方法:

使用HRMS,NMR,IR和TGA进行合成和表征.
单晶X射线晶体学用于结构阐明.
在体外细胞毒性测定对MCF7和HepG2细胞系.
紫外线吸收,光谱学和分子对接用于DNA相互作用研究.

主要成果:

六个复合体具有扭曲的五边形双金字塔形状的几何学成功合成和结构确认.
复合物2对MCF7和HepG2细胞增殖表现出显著的抑制作用,表现优于西斯.
综合体2通过间隔测定,通过光谱和计算方法支持,对小牛胸腺DNA表现出中度的亲和力.
结合相互作用导致复合体中1D或2D网络结构的形成.

结论:

合成的aroylhydrazone锡复合物具有独特的结构特征,并表现出有希望的抗癌特性.
复合物2代表了作为抗癌剂进一步开发的潜在化合物.
基因干机制为这些锡复合体的生物活性提供了洞察力.

关键词:

亚利甲基甲基化.生物活动是生物活动.晶体结构晶体结构有机蛋白是有机蛋白中的一种.综合合成综合合成

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