儿童囊细胞性死性淋巴腺炎的临床特征
1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, People's Republic of China.
European journal of pediatrics
|December 23, 2023
概括
儿童的囊细胞性死性淋巴腺炎 (HNL) 往往伴有长期发烧和白血病,模仿其他疾病. 多学科团队的早期识别对于避免误诊和改善结果至关重要.
科学领域:
- 儿科医学 儿科医学
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 囊性死性淋巴腺炎 (HNL) 与发烧,白血病和来源不明的淋巴腺病有关.
- 从传染病原因区分HNL依赖于组织学和免疫组织化学,因为它缺乏中性粒细胞或乙素粒细胞.
- HNL通常是自我限制的,但往往不适当地用抗生素和类固醇治疗.
研究的目的:
- 在儿科患者中研究囊性死性淋巴腺炎 (HNL) 的临床特征.
- 确定与儿科HNL.Nl的宫外淋巴结参与相关的因素.
- 提高儿童HNL的诊断准确度和管理.
主要方法:
- 对61名儿科患者的回顾性分析,这些患者在组织病理学上确诊了HNL.
- 收集和审查临床,实验室,组织学,治疗和结果数据.
- 多变量分析,以确定临床特征与疾病特征之间的关联,包括淋巴结参与和发烧持续时间.
主要成果:
- 该研究包括61名儿科患者 (平均年龄9.7岁;男性:女性比例2.2:1) 患有HNL.
- 发烧普遍存在,平均持续时间为22天;较高的高峰温度 (≥40°C) 与较长的发烧持续时间相关.
- 在患有长期发烧的患者中,白血症很常见 (68.9%),并且在单独的宫淋巴结中比宫外淋巴结更频繁 (82.4%对52.9%,p=0.027).
结论:
- 在患有持续发烧和淋巴腺病的儿童中,HNL经常被误诊,导致诊断延迟和不适当的治疗.
- 涉及初级保健,风湿病学和病理学的多学科方法对于准确的诊断和改善患者结果至关重要.
- 提高对HNL临床和实验室特征的认识可以防止不必要的调查,并指导适当的管理策略.
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